At some point “Auto Quick Info” got annoying. Now I have it set to pop up on middle-mouse click.
Install X-Mouse Button Control
In Visual Studio, go Options->Text Editor->C/C++->Advanced, IntelliSense, Auto Quick Info, disable.
In XMBC, add a new profile for devenv.exe
Add a SimulatedKeys rule for your mouse button (I used middle).
Only send if the profile is active (I assume that’s important?).